Affiliation:
1. Department of Anesthesia, GD Spl, MH- Allahabad
2. Asst. Prof. (Department of Anesthesia), GMC, Azamgarh
3. Prof. & HOD (Department of Anesthesia), GMC, Azamgarh
Abstract
Introduction-: The present study was designed to compare the effect of two intrathecal α-2 agonists with
bupivacaine in spinal anesthesia for urological procedures. Patients undergoing urological procedures
under spinal anaesthesia are usually elderly having comorbid conditions. α-2 agonists is being used as an adjuvant in spinal
anaesthesia with improved quality of anaesthesia and analgesia and minimal side effects. Aims and objectives-: The aim of
this study is to compare the effects of intrathecal dexmedetomidine and clonidine as adjuvants to hyperbaric bupivacaine with
respect to onset and duration of sensory and motor blockade duration of analgesia and incidence of side effects. Materials
and methods-: This study was conducted in the Department of Anaesthesiology at a tertiary care hospital in Mumbai, from July
2014 to June 2016 with prior permission from the Institute Ethics Committee after fullling all the criteria. 90 patients (Age
between 21-75 years, and weight 50 kg and above) undergoing various elective urological surgeriesunder subarachnoid
blockin Department of Anaesthesiology and Critical Care were enrolled in the study. Result- The duration of anaesthesia was
signicantly longer (p-value < 0.05) in Group B (Mean 442.87, SD 48.31, SE 11.11) in comparison with Group A (Mean 261.11,
SD 39.56, SE 7.78) and Group C (Mean 335.91, SSD 29.98, SE 9.93). Hence it's apparent that addition of Dexmedetomidine or
Clonidine to Hyperbaric Bupivacaine signicantly prolonged the duration of anaesthesia. Conclusions: α2-agonists with
hyperbaric bupivacaine intrathecally have a faster onset of both motor and sensory block. It also prolongs the duration of
analgesia.
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