COMPARISON OF BASAL-CELL SPECIFIC MARKERS – P63 AND 34BETAE12 IN PROSTATIC GLANDULAR PROLIFERATIONS
Author:
Jessica Akoijam Ningthibi1, Deepak Kumar Laishram2, Khuraijam Sushma3, Kaku Akoijam4, Laisom Alpana4
Affiliation:
1. Senior Resident, Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur 2. Assistant Professor, Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur. 3. Professor and Head of Department, Department of Pathology, Regional Institute of Medical Sciences, Imphal, Manipur. 4. Professor and Head of Department, Department of Urology, Regional Institute of Medical Sciences, Imphal, Manipur.
Abstract
Background: The prostate is a retroperitoneal organ encircling the neck of the bladder and urethra.
Though the diagnosis of the prostatic lesions are analyzed through histopathological examination
(HPE), sometimes, diagnosis can be challenging, when pathologist are faced with certain problems such as small foci of Ca or
benign mimickers. In such situation, immunohistochemical (IHC) detection of basal cells are widely used. To Objectives:
assess the expression of basal cell markers (p63 and 34betaE12) in various prostatic glandular proliferations and to
differentiate suspicious glandular lesions as benign or malignant. A two year cross-sectional s Methods: tudy (Sept'2016
–Aug'2018) , total of 52 cases of both TURP and prostate biopsy specimens sent to the department of Pathology, RIMS for HPE
were studied using IHC markers p63 and 34betaE12, following H&E stain and the expressions of the markers were studied.
Results: Out of 52 cases, 41(78.8%) cases were diagnosed as Benign proliferative hyperplasia (BPH), 8(15.4%) cases as
prostatic carcinoma, 2(3.8%) cases as high grade prostatic intraepithelial neoplasia (HGPIN) and one (1.9%) case of
adenoleiomyobromatous hyperplasia (AMFH) on H&E section with age range of 51 to 90 years (mean age: 72 years).
Following IHC staining, 43 (97.7%) benign cases were positive for both p63 and 34betaE12, one (2.3%) case of benign lesion
was negative for both the IHCs. 8(100%) cases of malignant lesions were negative for both the IHCs. A p-value of 1.000 was
observed indicating that there is no signicant difference in the sensitivity of p63 and 34betaE12. In this cross- Conclusion:
sectional study of 52 cases of prostatic lesions, HPE and the role of basal cell specic IHC markers p63 and 34beta12 were
studied. No signicant difference was observed in the sensitivity between the two markers. Further comparative study with
larger sample size is needed to comprehend the differences in the utility of p63 and 34etaE12 in diagnosing suspicious
prostatic lesions.
Publisher
World Wide Journals
Subject
Animal Science and Zoology,Ecology, Evolution, Behavior and Systematics,Health Professions (miscellaneous),Law,Public Health, Environmental and Occupational Health,Nutrition and Dietetics,Applied Microbiology and Biotechnology,Food Animals,Management Science and Operations Research,Strategy and Management,Business and International Management,General Business, Management and Accounting,Management of Technology and Innovation,Strategy and Management,Economics and Econometrics,Business and International Management,Management Science and Operations Research,Safety, Risk, Reliability and Quality,Business and International Management,Industrial and Manufacturing Engineering,Management Science and Operations Research,Economics and Econometrics,General Business, Management and Accounting,Industrial and Manufacturing Engineering,Management Science and Operations Research,Strategy and Management
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