Abstract
Introduction: AMH is an indicator of functional ovarian reserve, it is used in combination with other
biochemical and radiological markers in assessing fertility status in women, selecting candidates for IVF
stimulation, predicting menopause, diagnosis and management of PCOS. AMH alone may be considered for a good ovarian
reserve, either low or high will give an indication of primary ovarian failure or anovulatory cycles as seen in polycystic ovarian
syndrome respectively. With this basic investigation all the other hormones are added on to rule out the spectrum of differential
diagnosis and plan IVF treatments.
Materials and methods: A retrospective observational study was conducted in 38811 female patients 18 to 45 years of age,
divided into 2 groups; abnormal AMH (Group I), and normal AMH values (Group II) as per biological reference ranges for age.
Group I was further sub divided into Low AMH Group Ia, and High AMH group Ib, (lower and higher than the cut off for age)
respectively. FSH, LH, LH/FSH ratio, E2, Progesterone, DHEAS, Free testosterone, FT3, FT4, TSH, and fasting insulin were
studied in these groups.
Results: Statistical analyses were performed using “R Studio version 1.4.1103”. A two-tailed p value of <0.05 was considered
statistically signicant. Kruskal Wallis test was used for comparison of continues variables (Hormones) between the groups. A
chi-square categorical test shows statistical signicance of difference in values of FSH, LH, LH/FSH ratio, Free and total
testosterone, progesterone, fasting insulin, DHEAS and Free T3. No statistical signicance was seen with Prolactin, TSH, Free
T4, and E2.
Conclusion:Variation of normal and abnormal AMH levels with endogenous hormones plays a vital role in better interpretation
of AMH. FSH, LH, free testosterone, fasting insulin, Free T3, signicantly correlate in patients with Normal AMH levels.