CYTOKERATINS: NOT AN EPITHELIAL ENTITY ANYMORE?
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Published:2022-10-01
Issue:
Volume:
Page:15-16
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ISSN:
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Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
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language:en
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Short-container-title:ijsr
Author:
Kaur Geetpriya1, Shetty Devicharan2, Sikka Seema3, Pathak Aparna4
Affiliation:
1. Associate Professor, IDSTDental College, Meerut. 2. HOD, Department of Oral Pathology, ITS Dental College, Murad Nagar. 3. Consultant, Paradise Diagnostics. 4. Consultant, Paradise Diagnostics
Abstract
Cytokeratins are proteins of keratin-containing intermediate laments found in the intracytoplasmic cytoskeleton of epithelial cells. Cytokeratins
are represented in epithelial tissue by at least 20 different polypeptides. They range in molecular weight between 40KDa and 60KDa and isoelectric
pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. Cytokeratin 1 has the highest molecular weight and highest
isoelectric pH, while CK19 has the lowest molecular weight and a low isoelectric pH. Cytokeratins are divided into type I and type II subgroups.
The detection of cytokeratins in neoplasms by immunohistochemistry has numerous diagnostic and investigative applications. The patterns of
cytokeratin expression in the normal epithelium, as well as their altered expression in premalignant lesions and malignancies, might suggest newer
diagnostic improvements for positive patient outcomes.
Publisher
World Wide Journals
Subject
Insect Science,Ecology, Evolution, Behavior and Systematics,Physical and Theoretical Chemistry,General Physics and Astronomy,General Chemical Engineering,General Physics and Astronomy,General Mathematics,Fluid Flow and Transfer Processes,General Physics and Astronomy,Mechanical Engineering,General Materials Science,Fluid Flow and Transfer Processes,General Physics and Astronomy,Mechanical Engineering,Physical and Theoretical Chemistry,General Physics and Astronomy,General Chemical Engineering,Fluid Flow and Transfer Processes,Mechanical Engineering,Condensed Matter Physics,Cellular and Molecular Neuroscience,Developmental Neuroscience,Neurology,General Medicine,Literature and Literary Theory,Linguistics and Language,Language and Linguistics
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