Affiliation:
1. Assistant professor, Department of Pediatrics, Patna Medical College and Hospital,Patna.
Abstract
Objective: To compare the efficacy of metered dose inhaler with spacer with dry powder inhaler for delivery of
salbutamol in acute exacerbation of bronchial asthma Design:Randomized controlled trial in the Setting of Department
of Pediatrics, Patna Medical College and Hospital Patna Methods: Children in the age group of 5 - 12 years who
presented with a mild or moderate acute exacerbation of asthma were randomized to receive 400 mcg salbutamol by
either a MDI with spacer or a DPI. The changes in the wheezing and accessory muscle scores, SaO2, and PEFR were
recorded and subjected to statistical tests for significance. Results: Two hundred and fifty-three children were studied;
128 were assigned to the MDI-spacer group and 125 to rotahaler (DPI) group. After receiving treatment, the PEFR
improved by about 11% in both the groups. The oxygen saturation increased by 2% in both the groups.Within each
group, the improvement in PETR, SaO2, wheeze and accessory muscle score after the treatment was statistically
significant. Conclusion: Metered dose inhaler with spacer and dry powder inhaler are equally effective in delivering
salbutamol in therapy of mild to moderate acute exacerbations of bronchial asthma in children between 5-12 years of
age.
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