TO EVALUATE AND COMPARE THE POSSIBLE ANALGESIC PROPERTIES OF SEVOFLURANE WITH DESFLURANE IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMIES UNDER VOLATILE INDUCTION AND MAINTENANCE ANAESTHESIA (VIMA)

Abstract

Introduction: Sevourane and desurane have been successfully used in labour analgesia. Need more evidence to prove their analgesic properties, intraoperatively and postoperatively, when used in volatile induction maintenance Anaesthesia (VIMA) for laparoscopic cholecystectomy. So, a randomized study single blinded comparative study was carried out. After obtaining appropriate approvals, 50 Method: consenting patients of either gender were randomly, equally allocated to two groups to be anaesthetized with VIMA, using either sevourane and desurane. Monitoring included, in addition to routine multiparametric monitoring, the depth of anaesthesia monitoring using Conox, qCON/qNOX kept between 40-60. Rest of the anaesthesia technique was similar, inclusive of Inj. Fentanyl, in both the groups. Pain was scored using, visual analogue scale (VAS), just before induction (T0), just after extubation (T1), as shifted to Post Anaesthesia Care Unit (PACU) (T2), and on demand of rescue analgesia/2 hours in PACU, whichever came rst (T3). With achievement of adequate modied Aldrete score, adequate rescue analgesia was administered before shifting to the ward. Demographically, pati Results: ents in both the groups were similar. Except for lowering of mean pulse rate intraoperatively as compared to before induction, the haemodynamic parameters remained steadfastly stable, suggesting, potentiation of fentanyl analgesia with appropriate depth of anaesthesia maintained. VAS scores were consistently lower (1-3), at all the timepoints. Recovery although far superior in the desurane group was also adequate even in sevourane group. In face of low VAS, the rescue analgesia, had to be given pre-emptively before shifting to the ward. It appears that, both the IAAs Conclusion: , seem to have signicant intraoperative and postoperative analgesic efcacy. Desurane has rapid onset of analgesia, starting from time of induction. Amongst themselves the efcacy is similar, but recovery in desurane group appears to be faster than sevourane.