DIFFERENT TYPES OF BIO ACTIVE COUMARIN DERIVATIVES AS PROMISING CANDIDATES FOR ANTI TUBERCULAR THERAPY AND THEIR STRUCTURE ACTIVITY RELATIONSHIP (SAR) STUDIES

Abstract

Tuberculosis is one the most deadliest diseases. In recent years, showed drug Mycobacterium Tuberculosis resistance property which is a global threat in recent years. In order to get remedy of this disease, various kinds of novel drugs have been developed. Coumarin is a compound whose chemistry has been widely researched on. Hundreds of its derivatives have been reported from researchers across the globe. Findings amply suggest that coumarin derivatives have novel bioactive utility. Some of them have shown potent antiTB activity as well. Particularly in a country like India which is still miles away from eradicating TB and the multi-Drug resistant variety, the search for novel compounds continues to attract researchers. This review mainly represents various kinds of bio active Coumarin derivatives as signicant anti-TB agents, and their structure activity relationship.