EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SIDDHA HERBOMINERAL FORMULATION RATHINAGARA RASA MEZHUGU IN ANIMAL MODEL

Abstract

The usage of Nonsteroidal and steroidal drugs in the treatment of Musculoskeletal disorders often results in adverse effects such as renal damage, gastric irritation, etc. Alternative therapies with less or no side effects are the need of the hour. Siddha system offers a lot of Anti-inammatory drugs that are polyherbal or Herbo-mineral in nature and devoid of the above-mentioned adverse effects. This research work deals with the Anti-inammatory screening of a Siddha Herbo-mineral Formulation Rathinagara rasa mezhugu (RNM) documented in classic Siddha literature Anuboga vaidhaya naveneetham Part 5 indicated for inammatory disease conditions. Anti-inammatory activity was evaluated by Carrageenan-induced paw edema in Wistar rats. Indomethacin (10 mg/kg, orally) was used as standard. The formulation in doses of 20mg/kg, 45mg/kg, and 90 mg/kg showed 56%, 61.53%, and 90.47% inhibition of paw edema, respectively at the end of 5 h. The result of the study showed that RNM at all dose levels signicantly(p<0.5) reduced the inammation in a dose-dependent manner when compared to the control. RNM at 90mg/kg was found to be signicant (**p<0.01) and effective in the reduction of paw edema after 5hrs.From the results, it can be concluded that Rathinagara rasa mezhugu (RNM) was found to exhibit high anti-inammatory potential which conrmed the traditional use of the drug.