Lower Serum Creatinine Is a New Risk Factor of Type 2 Diabetes-Reference-Cited by-同舟云学术

Lower Serum Creatinine Is a New Risk Factor of Type 2 Diabetes

Published:2009-03-01 Issue:3 Volume:32 Page:424-426
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Harita Nobuko¹,Hayashi Tomoshige¹,Sato Kyoko Kogawa¹,Nakamura Yoshiko²,Yoneda Takeshi¹,Endo Ginji¹,Kambe Hiroshi¹²

Affiliation:

1. Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan

2. Kansai Health Administration Center, Nippon Telegraph and Telephone West Corporation, Osaka, Japan

Abstract

OBJECTIVE—Because skeletal muscle is one of the target tissues for insulin, skeletal muscle mass might be associated with type 2 diabetes. Serum creatinine is a possible surrogate marker of skeletal muscle mass. The purpose of this study was to determine whether serum creatinine level is associated with type 2 diabetes. RESEARCH DESIGN AND METHODS—The study participants were nondiabetic Japanese men (n = 8,570) aged 40–55 years at entry. Type 2 diabetes was diagnosed if fasting plasma glucose was ≥126 mg/dl or if participants were taking oral hypoglycemic medication or insulin. RESULTS—During the 4-year follow-up period, 877 men developed type 2 diabetes. Lower serum creatinine was associated with an increased risk of type 2 diabetes. The multiple-adjusted odds ratio for those who had serum creatinine levels between 0.40 and 0.60 mg/dl was 1.91 (95% CI 1.44–2.54) compared with those who had levels between 0.71 and 0.80 mg/dl. CONCLUSIONS—Lower serum creatinine increased the risk of type 2 diabetes.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/32/3/424/600518/zdc00309000424.pdf

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