Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis-Reference-Cited by-同舟云学术

Differentiation of Diabetes by Pathophysiology, Natural History, and Prognosis

Published:2016-12-15 Issue:2 Volume:66 Page:241-255
ISSN:0012-1797
Container-title:Diabetes
language:en
Short-container-title:

Author:

Skyler Jay S.¹^ORCID,Bakris George L.²,Bonifacio Ezio³^ORCID,Darsow Tamara⁴^ORCID,Eckel Robert H.⁵^ORCID,Groop Leif⁶^ORCID,Groop Per-Henrik⁷⁸⁹,Handelsman Yehuda¹⁰,Insel Richard A.¹¹,Mathieu Chantal¹²,McElvaine Allison T.⁴^ORCID,Palmer Jerry P.¹³,Pugliese Alberto¹,Schatz Desmond A.¹⁴^ORCID,Sosenko Jay M.¹⁵,Wilding John P.H.¹⁶^ORCID,Ratner Robert E.⁴

Affiliation:

1. Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL

2. The University of Chicago Medicine, Chicago, IL

3. Technische Universität Dresden, Dresden, Germany

4. American Diabetes Association, Arlington, VA

5. University of Colorado Anschutz Medical Campus, Aurora, CO

6. Lund University, Skåne University Hospital, Malmö, Sweden

7. Abdominal Center Nephrology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland

8. Folkhälsan Institute of Genetics, Folkhälsan Research Center, Helsinki, Finland

9. Baker IDI Heart and Diabetes Institute, Melbourne, Australia

10. Metabolic Institute of America, Tarzana, CA

11. JDRF, New York, NY

12. Katholieke Universiteit Leuven, Leuven, Belgium

13. University of Washington and VA Puget Sound Health Care System, Seattle, WA

14. University of Florida College of Medicine, Gainesville, FL

15. University of Miami Miller School of Medicine, Miami, FL

16. University Hospital Aintree, Liverpool, U.K.

Abstract

The American Diabetes Association, JDRF, the European Association for the Study of Diabetes, and the American Association of Clinical Endocrinologists convened a research symposium, “The Differentiation of Diabetes by Pathophysiology, Natural History and Prognosis” on 10–12 October 2015. International experts in genetics, immunology, metabolism, endocrinology, and systems biology discussed genetic and environmental determinants of type 1 and type 2 diabetes risk and progression, as well as complications. The participants debated how to determine appropriate therapeutic approaches based on disease pathophysiology and stage and defined remaining research gaps hindering a personalized medical approach for diabetes to drive the field to address these gaps. The authors recommend a structure for data stratification to define the phenotypes and genotypes of subtypes of diabetes that will facilitate individualized treatment.

Publisher

American Diabetes Association

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://journals.org/diabetes/diabetes/article-pdf/66/2/241/536991/db160806.pdf

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