Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk-Reference-Cited by-同舟云学术

Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk

Published:2013-03-14 Issue:4 Volume:36 Page:1012-1019
ISSN:0149-5992
Container-title:Diabetes Care
language:en
Short-container-title:

Author:

Brand Judith S.¹,van der Schouw Yvonne T.¹,Onland-Moret N. Charlotte¹,Sharp Stephen J.²,Ong Ken K.²,Khaw Kay-Tee³,Ardanaz Eva⁴⁵,Amiano Pilar⁵⁶⁷,Boeing Heiner⁸,Chirlaque Maria-Dolores⁵⁹,Clavel-Chapelon Françoise¹⁰,Crowe Francesca L.¹¹,de Lauzon-Guillain Blandine¹⁰¹²,Duell Eric J.¹³,Fagherazzi Guy¹⁰¹²,Franks Paul W.¹⁴¹⁵,Grioni Sara¹⁶,Groop Leif C.¹⁷¹⁸,Kaaks Rudolf¹⁹,Key Timothy J.¹¹,Nilsson Peter M.²⁰,Overvad Kim²¹²²,Palli Domenico²³,Panico Salvatore²⁴,Quirós J. Ramón²⁵,Rolandsson Olov²⁶,Sacerdote Carlotta²⁷²⁸,Sánchez María-José⁵²⁹,Slimani Nadia³⁰,Teucher Birgit¹⁹,Tjonneland Anne³¹,Tumino Rosario³²³³,van der A Daphne L.³⁴,Feskens Edith J.M.³⁵,Langenberg Claudia²,Forouhi Nita G.²,Riboli Elio³⁶,Wareham Nicholas J.²,

Affiliation:

1. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands

2. Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.

3. Department of Public Health and Primary Care, University of Cambridge, Addenbrooke's Hospital, Cambridge, U.K.

4. Navarre Public Health Institute, Pamplona, Spain

5. Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública), Madrid, Spain

6. Public Health Division of Gipuzkoa, Basque Government, San Sebastian, Spain

7. Instituto BIO-Donostia, Basque Government, San Sebastian, Spain

8. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany

9. Department of Epidemiology, Murcia Regional Health Council, Murcia, Spain

10. INSERM, Centre for Research in Epidemiology and Population Health (CESP), U1018: Nutrition, Hormones and Women's Health, Institut Gustave Roussy (IGR), Villejuif, France

11. Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, U.K.

12. University Paris Sud 11, UMRS 1018, Villejuif, France

13. Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, L'Hospitalet de Lolgbregat, Barcelona, Spain

14. Department of Clinical Sciences, Clinical Research Center, Malmö General Hospital, Lund University, Malmö, Sweden

15. Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden

16. Fondazione IRCCS Istituto Nazionale Tumori di Milano, Milan, Italy.

17. Department of Clinical Sciences, Diabetes and Endocrinology, University Hospital Scania, Lund University, Malmö, Sweden

18. Insitute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

19. Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany

20. Department of Clinical Sciences, University Hospital Scania, Lund University, Malmö, Sweden

21. Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark

22. Department of Cardiology, Aalborg Hospital, Aarhus University Hospital, Aalborg, Denmark

23. Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute, Florence, Italy

24. Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy

25. Consejería de Sanidad, Public Health Directorate, Oviedo-Asturias, Spain

26. Department of Public Health and Clinical Medicine, Family Medicine, Umea University, Umea, Sweden

27. Center for Cancer Prevention (CPO-Piemonte), Torino, Italy

28. Human Genetic Foundation, Torino, Italy

29. Andalusian School of Public Health, Granada, Spain

30. International Agency for Research on Cancer, Dietary Exposure Assessment Group, Lyon, France

31. Danish Cancer Society Research Center, Strandboulevarden Copenhagen, Denmark

32. Cancer Registry and Histopathology Unit, “Civile - M.P. Arezzo” Hospital, Azienda Sanitaria Provinciale No. 7, Ragusa, Italy

33. Associazone Iblea per la Ricerca Epidemiologica–Onlus, Ragusa, Italy

34. National Institute for Public Health and the Environment, Bilthoven, the Netherlands

35. Section of Nutrition and Epidemiology, Division of Human Nutrition, University of Wageningen, Wageningen, the Netherlands

36. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, U.K.

Abstract

OBJECTIVE Age at menopause is an important determinant of future health outcomes, but little is known about its relationship with type 2 diabetes. We examined the associations of menopausal age and reproductive life span (menopausal age minus menarcheal age) with diabetes risk. RESEARCH DESIGN AND METHODS Data were obtained from the InterAct study, a prospective case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition. A total of 3,691 postmenopausal type 2 diabetic case subjects and 4,408 subcohort members were included in the analysis, with a median follow-up of 11 years. Prentice weighted Cox proportional hazards models were adjusted for age, known risk factors for diabetes, and reproductive factors, and effect modification by BMI, waist circumference, and smoking was studied. RESULTS Mean (SD) age of the subcohort was 59.2 (5.8) years. After multivariable adjustment, hazard ratios (HRs) of type 2 diabetes were 1.32 (95% CI 1.04–1.69), 1.09 (0.90–1.31), 0.97 (0.86–1.10), and 0.85 (0.70–1.03) for women with menopause at ages <40, 40–44, 45–49, and ≥55 years, respectively, relative to those with menopause at age 50–54 years. The HR per SD younger age at menopause was 1.08 (1.02–1.14). Similarly, a shorter reproductive life span was associated with a higher diabetes risk (HR per SD lower reproductive life span 1.06 [1.01–1.12]). No effect modification by BMI, waist circumference, or smoking was observed (P interaction all > 0.05). CONCLUSIONS Early menopause is associated with a greater risk of type 2 diabetes.

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://diabetesjournals.org/care/article-pdf/36/4/1012/615893/1012.pdf

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