Affiliation:
1. From the Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Abstract
OBJECTIVE
To explore the association between epistasis among related genes of the renin-angiotensin system (RAS) and type 2 diabetes.
RESEARCH DESIGN AND METHODS
Gene polymorphisms were genotyped in 394 type 2 diabetic patients and 418 healthy control subjects in this case-control study. We used the multifactor dimensionality reduction method to identify gene-gene interactions.
RESULTS
No single locus was associated with type 2 diabetes, except for the insert/deletion (I/D) polymorphism of the ACE gene in female subjects. In multi-locus analyses, in male subjects the model of rs2106809 (ACE2), rs220721 (Mas), rs699 (AGT), and I/D (ACE) was significant (P = 0.043). This combination was associated with a 4.00 times (95% CI 2.51–6.38; P < 0.0001) greater prevalence of type 2 diabetes. In female subjects, the model of rs2106809 (ACE2), I/D (ACE), and rs1403543 (AGTR2) was significant (P = 0.012). This three-locus combination was associated with a 2.76 times (1.91–3.97; P < 0.0001) greater prevalence of type 2 diabetes.
CONCLUSIONS
Interactions among RAS-related genes were associated with type 2 diabetes in a Chinese population.
Publisher
American Diabetes Association
Subject
Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
24 articles.
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