Inhibition of IL-1β Improves Fatigue in Type 2 Diabetes

Author:

Cavelti-Weder Claudia1,Furrer Romana1,Keller Cornelia1,Babians-Brunner Andrea1,Solinger Alan M.2,Gast H.3,Fontana A.4,Donath Marc Y.1,Penner Iris K.5

Affiliation:

1. From the Division of Endocrinology, Diabetes and Metabolism, University Hospital Basel, Basel, Switzerland;

2. Clinical Development, XOMA (U.S.), Berkeley, California; the

3. Department of Neurology, Inselspital, University Berne, Berne, Switzerland; the

4. Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland; and the

5. Department of Cognitive Psychology and Methodology, University of Basel, Basel, Switzerland

Publisher

American Diabetes Association

Subject

Advanced and Specialized Nursing,Endocrinology, Diabetes and Metabolism,Internal Medicine

Reference5 articles.

1. TNF-alpha suppresses the expression of clock genes by interfering with E-box-mediated transcription;Cavadini;Proc Natl Acad Sci USA,2007

2. Interleukin-1-receptor antagonist in type 2 diabetes mellitus;Larsen;N Engl J Med,2007

3. XOMA 052, an anti-IL-1β antibody, in a double blind, placebo controlled, dose escalation study of the safety and pharmacokinetics in patients with type 2 diabetes mellitus – a new approach to therapy;Donath;Diabetologia,2008

4. The Fatigue Scale for Motor and Cognitive Functions (FSMC): validation of a new instrument to assess multiple sclerosis-related fatigue;Penner;Mult Scler,2009

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