Affiliation:
1. Department of Medicine, University of Sydney, and the Department of Endocrinology, Royal Prince Alfred Hospital Sydney, NSW, Australia
Abstract
This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2–9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Cited by
63 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献