Discrimination Between Obesity and Insulin Resistance in the Relationship With Adiponectin
Author:
Abbasi Fahim1, Chu James W.1, Lamendola Cindy1, McLaughlin Tracey1, Hayden John2, Reaven Gerald M.1, Reaven Peter D.2
Affiliation:
1. Divisions of Cardiovascular Medicine and Endocrinology and Metabolism, Department of Medicine, Stanford University School of Medicine, Stanford, California 2. Division of Endocrinology and Metabolism, Department of Medicine, Carl T. Hayden Veterans Affairs Medical Center, Phoenix, Arizona
Abstract
Insulin resistance and obesity are both associated with lower plasma adiponectin concentrations. Since insulin resistance and obesity are related, the extent to which the association of adiponectin with insulin resistance is dependent on its relationship with obesity is unclear. To address this issue, fasting plasma adiponectin concentrations were measured in 60 nondiabetic subjects, stratified into four equal groups on the basis of both their degree of adiposity and insulin resistance. Insulin resistance was quantified by determining the steady-state plasma glucose (SSPG) concentration in response to an infusion of octreotide, glucose, and insulin, and degree of adiposity was assessed by BMI. Subjects were defined as obese (BMI ≥30.0 kg/m2) or nonobese (<27.0 kg/m2) and as either insulin sensitive (SSPG <100 mg/dl) or insulin resistant (>190 mg/dl). Insulin-resistant subjects had significantly (P<0.001) lower (mean ± SD) adiponectin concentrations, whether they were obese (17.1 ± 5.9 μg/ml) or nonobese (16.3 ± 7.5 μg/ml) as compared with either obese, insulin-sensitive (34.3 ± 13.1 μg/ml) or nonobese, insulin-sensitive (29.8 ± 15.3 μg/ml) subjects. Finally, adiponectin levels in insulin-sensitive subjects varied to a significantly greater degree than in insulin-resistant subjects. These results suggest that adiponectin concentrations are more closely related to differences in insulin-mediated glucose disposal than obesity.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
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