Affiliation:
1. From the Mayo College of Medicine, Mayo Clinic, Rochester, Minnesota
Abstract
The proposed contribution of glucose variability to the development of the complications of diabetes beyond that of glycemic exposure is supported by reports that oxidative stress, the putative mediator of such complications, is greater for intermittent as opposed to sustained hyperglycemia. Variability of glycemia in ambulatory conditions defined as the deviation from steady state is a phenomenon of normal physiology. Comprehensive recording of glycemia is required for the generation of any measurement of glucose variability. To avoid distortion of variability to that of glycemic exposure, its calculation should be devoid of a time component.
Publisher
American Diabetes Association
Subject
Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference51 articles.
1. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus;The Diabetes Control and Complications Trial Research Group;N Engl J Med,1993
2. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and the risk of complications in patients with type 2 diabetes (UKPDS33);UK Prospective Diabetes Study (UKPDS) Group,1998
3. Should minimal BG variability become the gold standard of glycemic control?;Hirsch;J Diabetes Complications,2005
4. Motherhood, apple pie, hemoglobin A(1C), and the DCCT;Trence,2012
5. Effect of glycemic exposure on the risk of microvascular complications in the Diabetes Control and Complications Trial—revisited;Lachin;Diabetes,2008
Cited by
170 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献